Title:
ENCAPSULATION OF PANCREATIC CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS
Document Type and Number:
Japanese Patent JP2017197578
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide encapsulation of cells derived from human embryonic stem cells and other pluripotent human cells.SOLUTION: According to the present invention, there is provided a method for producing insulin in vivo in a mammal, the method comprising: (a) providing an in vitro human PDX1-positive pancreatic progenitor cell population into an implantable semi-permeable device; (b) implanting the device with the cell progenitor cell population into a mammalian host; and (c) maturing the progenitor cell population in the device in vivo such that the progenitor cell population comprises endocrine and acinar cells. Here, at least some of the endocrine cells are insulin secreting cells that produce insulin in response to glucose stimulation in vivo, thereby producing insulin in vivo to the mammal.SELECTED DRAWING: Figure 1
Inventors:
LAURA MARTINSON
CHAD GREEN
EVERT KROON
AGULNICK ALAN
OLIVIA KELLY
EMMANUEL E BAETGE
CHAD GREEN
EVERT KROON
AGULNICK ALAN
OLIVIA KELLY
EMMANUEL E BAETGE
Application Number:
JP2017146480A
Publication Date:
November 02, 2017
Filing Date:
July 28, 2017
Export Citation:
Assignee:
VIACYTE INC
International Classes:
A61K35/39; A61K9/48; A61P3/10; A61P5/50; C12M3/06; C12N5/0775; C12P21/00; A61K35/12
Domestic Patent References:
| JP2005501573A | 2005-01-20 | |||
| JPH08504615A | 1996-05-21 | |||
| JP2005511046A | 2005-04-28 | |||
| JP2002538779A | 2002-11-19 |
Other References:
NATURE BIOTECHNOLOGY, vol. 26, JPN6017010230, 2008, pages 443 - 452, ISSN: 0003788144
人工臓器, vol. 31(3), JPN6017010231, 2002, pages 96 - 99, ISSN: 0003788145
人工臓器, vol. 32(1), JPN6017010233, 2003, pages 37 - 45, ISSN: 0003788146
人工臓器, vol. 31(3), JPN6017010231, 2002, pages 96 - 99, ISSN: 0003788145
人工臓器, vol. 32(1), JPN6017010233, 2003, pages 37 - 45, ISSN: 0003788146
Attorney, Agent or Firm:
Yoshiyuki Kawaguchi