PURPOSE: An endermically absorbing agent useful as an external preparation having high endermically absorbing properties, having improved feeling in use, containing a specific amine derivative as an active ingredient.
CONSTITUTION: An endermically absorption promoter containing an amine derivative (e.g. dimethyloctylamine) shown by formula (R1WR3 are 1W36C saturated, unsaturated straight-chain or branched chain fatty aliphatic hydrocarbon, alicyclic hydrocarbon or 6W14C alkyl group-containing alkylphenyl) as an active ingredient. Since the amine derivative can regulate hydrophilic-lipophilic balance by properly selecting its structure, any base of hydrophilic or lipophilic nature can be prepared. An amine derivative having high solubility in various medicinal components can be selected and a slightly water-soluble medicinal components is dissolved in a hydrophilic base in high concentration to design an external preparation having improved feeling in use. the external preparation expects approximately the same medicinal effects as those of oral administration while side effects found in oral administration can be avoided.
MATSUO NOBORU
MORIOKA TOMONORI
HARA KENJI
| JPS59216818A | 1984-12-06 |
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