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Patent Searching and Data


Title:
ENDOTHELIN RECEPTOR-ANTAGONISTIC PEPTIDE
Document Type and Number:
Japanese Patent JPH07228594
Kind Code:
A
Abstract:

PURPOSE: To obtain a new compound having excellent antagonistic activity against endothelin receptors, useful as a medicine for circulatory diseases such as hypertension, arteriosclerosis and hyperlipemia, allergic diseases such as asthma, nephropathy such as renal insufficiency, etc.

CONSTITUTION: A compound of the formula (Xaa is Glu or Asp; (n) is 0 or 1; the linkage between Lys and Xaa is such that an amido linkage is formed between the α- or -amino group of Lys and the β- or γ-carboxyl group of Xaa). The compound of the formula can be obtained by synthesizing the noncyclic portion of a peptide using a peptide synthesizer followed by linking a cyclic portion synthesized separately to the noncyclic portion.


Inventors:
SHIMADA MITSUYUKI
NAKANISHI KYOKO
NAKATSUKA TAKASHI
ISHIGURO MASAJI
Application Number:
JP2107994A
Publication Date:
August 29, 1995
Filing Date:
February 18, 1994
Export Citation:
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Assignee:
SUNTORY LTD
International Classes:
A61K38/00; A61P9/00; A61P13/02; A61P15/00; A61P37/08; C07K7/06; (IPC1-7): C07K7/06; A61K38/00
Attorney, Agent or Firm:
Kyozo Yuasa (6 people outside)