内皮細胞特異的抗体およびその使用 - Kirin Holdings Company, Limited

Title:

内皮細胞特異的抗体およびその使用

Document Type and Number:

Japanese Patent JP4928259

Kind Code:

B2

Abstract:

Methods and composition provided herein relate to the inhibition of proliferation, migration, and tubule formation of endothelial cells and are thus useful in treating angiogenesis associated diseases, including cancer, polycystic kidney disease, diabetic retinopathy, rheumatoid arthritis, and psoriasis, Disclosed are methods of inhibiting endothelial cell proliferation, migration, and tubule formation by administering an antibody specific for Tumor EndothPelial Markers (TEMs). Also disclosed are methods of inhibiting angiogenesis and tumor growth by administering a TEM-specific antibody and antibody compositions useful in such methods.

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Inventors:

Teacher, beverly
Roberts, Bruce
Kataoka
Tomoyuki Tahara
Hiroyuki Homma

Application Number:

JP2006509156A

Publication Date:

May 09, 2012

Filing Date:

March 04, 2004

Export Citation:

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Assignee:

Kirin Holdings Company, Limited
Genzyme Corporation

International Classes:

A61K39/395; A61P9/00; A61P35/00; A61P35/02; C07K16/28; C07K16/30; C12N5/10; A61K48/00

Foreign References:

WO2002010217A2

2002-02-07

Attorney, Agent or Firm:

Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka

Previous Patent: JPS4928258

Next Patent: JPS4928260