Title:
増強されたキメラ抗原受容体およびその使用
Document Type and Number:
Japanese Patent JP7416695
Kind Code:
B2
Abstract:
The presently disclosed subject matter provides methods and compositions for enhancing the immune response toward cancers and pathogens. It relates to novel designs of chimeric antigen receptors (CARs) and engineered immunoresponsive cells comprising the same. The engineered immunoresponsive cells comprising the novel CARs are antigen-directed and have extended persistence without compromising function.
Inventors:
Saderain, Michael
Feucht, Judith
Hamieh, Mohammad
Seung, Jiae
Mancila-Soto, George A.
Feucht, Judith
Hamieh, Mohammad
Seung, Jiae
Mancila-Soto, George A.
Application Number:
JP2020535520A
Publication Date:
January 17, 2024
Filing Date:
December 31, 2018
Export Citation:
Assignee:
Memorial Sloan-Kettering Cancer Center
International Classes:
C12N15/62; A61K35/17; A61K39/395; A61P35/00; A61P35/02; C07K14/705; C07K14/725; C07K16/30; C07K19/00; C12N5/0735; C12N5/078; C12N5/0783; C12N5/0789; C12N5/10
Domestic Patent References:
| JP2015516818A |
Other References:
J Immunol.(2011)Vol.186, p.6839-6847
Clin Exp Immunol.(2014)Vol.175, No.2, p.258-267
J Immunol.(2009)Vol.183, p.5563-5574
Clin Exp Immunol.(2014)Vol.175, No.2, p.258-267
J Immunol.(2009)Vol.183, p.5563-5574
Attorney, Agent or Firm:
Shusaku Yamamoto
Natsuki Morishita
Natsuki Morishita