ENHANCED PRODUCTION OF LIPID CONTAINING POLYENOIC FATTY ACID BY HIGH DENSITY CULTURE OF EUKARYOTIC MICROORGANISM IN FERMENTOR

Japanese Patent JP2010057508

A

To provide a method for proliferating eukaryotic microorganisms which produce lipids, in particular lipids containing polyenoic fatty acids, and a method for producing lipids of the eukaryotic microorganisms.

There are provided the method for proliferating eukaryotic microorganisms producing at least about 20% of eukaryotic microorganism biomass as lipids, the method for producing lipids of the same, wherein the lipids preferably contain one or more polyenoic fatty acids, and a carbon source, preferably a non-alcohol carbon source, and restricted nutrient sources are added to a fermentation medium containing the eukaryotic microorganisms. The carbon source and the restricted nutrients are preferably added at a sufficient rate to increase biomass density of the fermentation medium at least at about 100 g/L.

REUCKER CRAIG M
DIMASI DON
HANSEN JON M
MIRRASOUL PETER J
BAILEY RICHARD B
VEEDER GEORGE T III
KANEKO TATSUO
BARCLAY WILLIAM R

JP2009282393A

March 18, 2010

December 14, 2009

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MARTEK BIOSCIENCES CORP

C12N15/09; A23B7/10; C12P7/64; A23D9/00; A23L29/00; A23L33/00; C12N1/00; C12N1/12; C12N1/13; C12R1/89

JPH09284A	1997-01-07
JPH05503425A	1993-06-10
JPH0965971A	1997-03-11
JPH05505726A	1993-08-26
JPH11285376A	1999-10-19

JPN4004008718; Ａｐｐｌ．　Ｍｉｃｒｏｂｉｏｌ．　Ｂｉｏｔｅｃｈｎｏｌ． Ｖｏｌ．３７, 1992, ｐｐ．１８-２２
JPN6008021422; Ｐｒｏｓｔａｇｌａｎｄｉｎｓ，　Ｌｅｕｋｏｔｒｉｅｎｅｓ　ａｎｄ　Ｅｓｓｅｎｔｉａｌ　Ｆａｔｔｙ　Ａｃｉｄｓ Ｖｏｌ．６８, 2003, ｐｐ．１８１-１８６
JPN6008021423; Ｐｒｏｃ．　Ｎａｔｌ．　Ａｃａｄ．　Ｓｃｉ．　ＵＳＡ Ｖｏｌ．９６, 1999, ｐｐ．３３３６-３３３８
JPN6012045859; Ｊｏｕｒｎａｌ　ｏｆ　Ｉｎｄｕｓｔｒｉａｌ　Ｍｉｃｒｏｂｉｏｌｏｇｙ，　１９９６，　Ｖｏｌ．１６，　ｐｐ．３７０-３７３

Hatsushi Shimizu
Koichi Niimi

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