Title:
芳香族化合物による核酸重合の強化
Document Type and Number:
Japanese Patent JP7323534
Kind Code:
B2
Abstract:
The invention relates to compounds, methods and compositions for improving on nucleic acid polymerization, including DNA replication by in vitro primer extension to generate, for example, polymers for nanopore-based single molecule sequencing of a DNA template. A nucleic acid polymerase reaction composition is provided with polymerization enhancement moieties, which allows enhanced DNA polymerase activity with nucleotide analogs, resulting in improved length of primer extension products for sequencing applications.
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Inventors:
Mark Stamatios Kokolis
John Tabone
Meld Navabi
Aaron Jacobs
Dylan O'connell
Drew Goodman
Rasay Merrill
Jagadeeswaran Chandrasekhar
Kendall Berg
Samantha Bellucci
Jessica Bellucci
John Tabone
Meld Navabi
Aaron Jacobs
Dylan O'connell
Drew Goodman
Rasay Merrill
Jagadeeswaran Chandrasekhar
Kendall Berg
Samantha Bellucci
Jessica Bellucci
Application Number:
JP2020537227A
Publication Date:
August 08, 2023
Filing Date:
December 27, 2018
Export Citation:
Assignee:
Stratos Genomics Incorporated
International Classes:
C12N15/09; C07D249/06; C07D401/14; C07D403/14; C12M1/00; C12N9/12; C12N15/11; C12Q1/686; C12Q1/6869; C12Q1/6876
Domestic Patent References:
| JP2010530759A | ||||
| JP2011041573A | ||||
| JP2011041572A | ||||
| JP2002505572A |
Foreign References:
| US20160145292 | ||||
| US20150284787 | ||||
| WO2017148860A1 | ||||
| WO2017050751A1 | ||||
| US20130143768 |
Other References:
Int. J. Mol. Sci.,2016年,Vol.17,1371
Org. Lett.,2015年,Vol.17,pp.5740-5743
Org. Lett.,2015年,Vol.17,pp.5740-5743
Attorney, Agent or Firm:
Toru Ishikawa