Enigma―Mdm2相互作用及びその用途

Japanese Patent JP5377358

B2

The present invention relates to Enigma (PDLIM7)-Mdm2 interaction and use thereof. More particularly, it may induce an effective apoptosis of cancer cells by inhibition of an Enigma expression or an Enigma activity which induces Mdm2 destabilization and p53 activity; it may assess the prognosis of anti-cancer therapy by determining that Enigma, which is induced by SRF, is overexpressed in cancer tissues with Mdm2; it may screen anti-cancer activity substances by selecting a factor to inhibit specific binding between Enigma and Mdm2. Enigma-Mdm2 interaction and Enigma expression regulation may be utilized usefully for preventing cancers and developing therapeutic methods and anti-cancer agents.

Jun Cho-Roku
Im Don't
Lim Jun-Fa
Choi Yun Jun

JP2010036003A

December 25, 2013

February 22, 2010

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KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

G01N33/53; G01N33/15; G01N33/50

JP2008072952A
JP2006514554A

American Journal of Pathology,2004年,Vol.164, No.3,p.903-914
Cancer Letters,2007年,Vol.246, No.1-2,p.129-138
Bioベンチャー,2003年,第3巻,第4号,p.14-17
医学のあゆみ,2006年,第217巻,第4号,p.309-313
バイオテクノロジージャーナル,2007年,第7巻,第3号,p.296-301
三菱京都病院医学総合雑誌,2006年,第13巻,p.10-19
実験医学,2001年,第19巻,第9号,p.1093-1096

Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Kazuya Kawamoto

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