Title:
エノラーゼ１（ＥＮＯ１）組成物及びその使用
Document Type and Number:
Japanese Patent JP6629234
Kind Code:
B2
Abstract:
The invention provides compositions comprising Eno1 for delivery to a muscle. Further, the invention provides a method for normalizing blood glucose in a subject with elevated blood glucose, comprising administering to the subject enolase 1 (Eno1), thereby normalizing blood glucose in the subject. The invention also provides methods of treating one or more conditions including impaired glucose tolerance, insulin resistance, pre-diabetes, and diabetes, especially type 2 diabetes in a subject, comprising administering to the subject enolase 1 (Eno1), thereby treating the condition in the subject. In certain methods of the invention, the Eno1 is delivered to muscle.
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Inventors:
Narain, Niven, Rajin
Sarangarayan, Ranga Prasad
Vishnudus, Vivek, Kay.
Gesta, Stephanu
Jin, Enshuan
Downert, Sylvia
Deo, Sapna, Kay.
Jimenez, Joaquin, Juan
Dixie, Emre
Daphtarian, Pillows, Mohammad
Sarangarayan, Ranga Prasad
Vishnudus, Vivek, Kay.
Gesta, Stephanu
Jin, Enshuan
Downert, Sylvia
Deo, Sapna, Kay.
Jimenez, Joaquin, Juan
Dixie, Emre
Daphtarian, Pillows, Mohammad
Application Number:
JP2016563909A
Publication Date:
January 15, 2020
Filing Date:
January 13, 2015
Export Citation:
Assignee:
Berg LLC
University of Miami
University of Miami
International Classes:
A61K38/51; A61K47/64; A61P3/10; A61P43/00
Domestic Patent References:
| JP2003522183A | ||||
| JP2010533171A |
Other References:
Free Radical Biology & Medicine,2010年,48,p.873-881
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Kosemura Akiko
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Kosemura Akiko