過負荷結合および溶出クロマトグラフィによる選択生成物アイソフォームの富化および濃縮

Japanese Patent JP2014503495

A

Disclosed is a method for enhancing or increasing the concentration of biological product in a final mixture, wherein said biological product has one or more selected characteristics, wherein said method comprises: (a) allowing an initial mixture of biological products with and without said selected characteristics to contact a chromatography medium wherein the quantity of biological products in said initial mixture exceeds the binding capacity or the dynamic binding capacity of said chromatography medium; (b) allowing biological product not having said one or more selected characteristics to be separated by said chromatography medium; and (c) recovering a final mixture of biological products from said chromatography medium wherein said final mixture comprises an enhanced or increased concentration of biological product with one or more selected characteristics, compared to the concentration of biological product in said initial mixture.

Radiwala, Asif
Piassie, john

JP2013538997A

February 13, 2014

November 15, 2011

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Biogen Idec Incorporated

C07K1/16; B01D15/08; B01J20/04; B01J20/26; B01J20/281; B01J20/34; B01J39/26; B01J41/20; B01J49/00; C07K1/18; C07K1/20; C07K1/22; G01N30/46; G01N30/88; G01N30/26; G01N30/34

JPH08503714A	1996-04-23
JP2008537153A	2008-09-11
JP2009518361A	2009-05-07
JP2007535919A	2007-12-13
JP2008540684A	2008-11-20
JP2005518196A	2005-06-23
JP2005520550A	2005-07-14
JP2008504008A	2008-02-14

WO2008120801A1	2008-10-09
US7294481B1	2007-11-13
US7300773B2	2007-11-27
US6528286B1	2003-03-04

Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto

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