Title:
ＵＤＰ－ＧｌｃＮＡｃの調製のための酵素的方法
Document Type and Number:
Japanese Patent JP7457112
Kind Code:
B2
Abstract:
The present invention relates to an enzyme-catalyzed process for producing UDP-N-acetyl-α-D-glucosamine (UDP-GlcNAc) from low-cost substrates uridine monophosphate and N-acetyl-D glucosamine in a single reaction mixture with immobilized or preferably co-immobilized enzymes. Further, said process may be adapted to produce GlcNAcylated molecules and biomolecules including saccharides, particularly human milk oligosaccharides (HMO), proteins, peptides, glycoproteins, particularly antibodies, or glycopeptides, and bioconjugates, particularly carbohydrate conjugate vaccines and antibody-drug conjugates.
Inventors:
Mahou Areza
Lexer Thomas F.T.
Lexer Thomas F.T.
Application Number:
JP2022525884A
Publication Date:
March 27, 2024
Filing Date:
September 30, 2020
Export Citation:
Assignee:
Max Planck Gezel Shaft Tour Federun del Wissen Schaften Afor
International Classes:
C12P19/32; C12N9/10; C12N9/12
Other References:
J. Biotechnol.,2018年,Vol.283,pp.120-129
Chem. Commun.,2002年,pp.2586-2587
Nat. Protoc.,2007年,Vol.2, No.5,pp.1022-1033
Chem. Commun.,2002年,pp.2586-2587
Nat. Protoc.,2007年,Vol.2, No.5,pp.1022-1033
Attorney, Agent or Firm:
Nagoya International Patent Attorney Corporation