To obtain a matrix metalloprotease inhibitor.
This matrix metalloprotease inhibitor contains a compound of general formula (I) {R1 is H or NHOH; R2 is H, a (substituted) alky, a cycloalkyl or a group of AR6 [A is an alkylene (interrupted by O, S(O)m or N(R9)); and R6 is a group of formulas (II), (III) or (IV); X is O, S, N(R10) or C(R11)(R12); Y is O, CO, S(O)n, N(R10) or C(R11)(R12); R7 and R8 are each H, an alkyl, COOH, a (substituted) alkyl, or the like, R9 to R12 are each H, an alkyl, or the like; and (m) and (n) are each 0-2]; R3 is H, a (substituted) alkyl, a (substituted) cycloalkyl, a (substituted) alkenyl or a (substituted) alkynyl; R4 is a (substituted) (hetero)arylene; and R5 is a (substituted) alkyl or a (substituted) (hetero)aryl}, a pharmaceutically acceptable salt, an ester or other derivative thereof.
MIYAZAKI SHOJIRO
UEDA KEIJI
TANZAWA KAZUHIKO
USHIYAMA SHIGERU
TAKASAKI WATARU
