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Title:
新生物を治療するためのErbB3に基づく方法および組成物
Document Type and Number:
Japanese Patent JP4660094
Kind Code:
B2
Abstract:
The present invention relates to compositions and methods for treating neoplasms in mammals, particularly humans. More particularly, the present invention provides for methods for preventing, treating or delaying neoplasm in a mammal using an ErbB-3 protein, a nucleic acid encoding an ErbB-3 protein or a functional fragment thereof. The present invention also provides for isolated nucleic acids encoding an extracellular domain of the ErbB-3 protein, or a functional fragment thereof, substantially purified extracellular domain of the ErbB-3 protein, or a functional fragment thereof and antibodies that bind to an epitope in an extracellular domain of the ErbB-3 protein, or a functional fragment thereof. The present invention further provides for pharmaceutical compositions and/or vaccines comprising the extracellular domain of the ErbB-3 protein, or a functional fragment thereof, or nucleic acids encoding and antibodies binding to such extracellular domain or functional fragments thereof.

Inventors:
Chow Min Dong
Application Number:
JP2003578561A
Publication Date:
March 30, 2011
Filing Date:
March 26, 2003
Export Citation:
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Assignee:
Zensan (Shanghai) Sai-Tech. Limited
International Classes:
C12N15/09; A61K31/7088; A61K38/00; A61K38/17; A61K39/00; A61K39/395; A61K48/00; A61P35/00; C07H21/00; C07K14/435; C07K14/47; C07K14/705; C07K16/28; C07K16/30; C07K16/32; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12P21/08
Domestic Patent References:
JP2000515372A
Other References:
Proc. Natl. Acad. Sci. USA.,1989年,Vol.86,p.9193-9197
Proc. Natl. Acad. Sci. USA.,1990年,Vol.87,p.4905-4909
Attorney, Agent or Firm:
Shoichi Okuyama
Arihara Koichi
Matsushima Tetsuo