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Title:
ERGOSTEROL GLYCOSIDE DERIVATIVE AND USE
Document Type and Number:
Japanese Patent JP3343063
Kind Code:
B2
Abstract:

PROBLEM TO BE SOLVED: To obtain the subject new derivative useful for a preventive/ therapeutic agent for diseases observed to have hyaluronic acid abnormal decomposition and decomposition accentuation, an inhibitor against hyaluronic acid decomposition, a preventive for chapped skin and dried skin, a cosmetic, etc., comprising a specific ergosterol glycoside.
SOLUTION: This new ergosterol glycoside derivative is shown by the formula, is expected to have preventing and treating effects on diseases followed by abnormal decomposition of hyaluronic acid and gingivitis, xeroderma, chapped skin, dried skin, etc., in which hyaluronic acid decomposition is more aggravated than a physiologically normal state and is useful as a medicine composition directly acting on fibroblast, an inhibitor against hyaluronic acid decomposition, a preventive for chapped skin and dried skin, a cosmetic, etc. The glycoside is obtained by extracting a lyophilized substance of a fruit body of Naemaroloma sublateritium a mushroom derived from the family Strophariaceae with an extraction solvent such as water, methanol, etc., filtering or centrifuging the extraction solution to remove impurities, concentrating the filtrate under reduced pressure, reextracting the concentrate with ethyl acetate and drying the extracted essence by lyophilization, etc.


Inventors:
Sakai, Shingo
Sayo, Tetsuya
Inoue, Shintaro
Kamio, Michiko
Kawagishi, Hirokazu
Hosokawa, Satoshi
Application Number:
JP1997000284405
Publication Date:
November 11, 2002
Filing Date:
September 30, 1997
Export Citation:
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Assignee:
KANEBO LTD
International Classes:
C12N9/99; A61K8/00; A61K31/575; A61P17/00; A61Q11/00; C07J17/00; (IPC1-7): C07J17/00; A61K7/00; A61K31/575; A61P17/00; C12N9/99