ステロイドスルファターゼのインヒビターとしてのエストロゲン誘導体

Japanese Patent JP4719144

B2

The present invention provides a compound comprising a steroidal ring system and an optional group R1 selected from any one of —OH, a sulphamate group, a phosphonate group, a thiophosphonate group, a sulphonate group or a sulphonamide group; wherein the D ring of the steroidal ring system is substituted by a group R2 of the formula -L-R3, wherein L is an optional linker group and R3 is selected from groups which are or which comprise one of a nitrite group, an alcohol, an ester, an ether, an amine and an alkene, provided that when R3 is or comprises an alcohol, L is present; and wherein the A ring of the steroidal ring system is substituted at position 2 or 4 with a group R4, wherein R4 is a hydrocarbyl group.

JP3590863	Liquid crystal compounds, liquid crystal additives and optical recording media with light-sensitive sites
WO/1996/003875	COMPOSITIONS FOR TARGETING MATERIALS TO CELLS CONTAINING ANDROGEN RECEPTORS
WO/2007/086883	CATIONIC LIPIDS AND FORMULATED MOLECULAR COMPOSITIONS CONTAINING THEM

Leeds, Matthew
Puro Hit, Alan
Reed, michael john
Newman, Simon Paul
Chandler, Slinder Kumar
Fabric, jordan
Potter, Barry Victor Lloyd

JP2006505892A

July 06, 2011

February 20, 2004

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C07J41/00; A61K31/56; A61K31/57; A61P9/00; A61P17/00; A61P25/06; A61P25/28; A61P29/00; A61P31/18; A61P35/00; A61P37/06; A61P43/00; C07J43/00; A61K31/565; A61K31/566; A61K31/573; C07J1/00; C07J3/00; C07J5/00; C07J7/00; C07J21/00; C07J31/00

JP2002510295A

WO2001085755A1
WO2002016395A1
WO2002016392A1
WO2000066095A1
WO2000434008A1
WO1999064013A1
WO1999033858A1
WO1999027936A1
EP1284272A1

MACCARTHY-MORROGH L,CANCER RESEARCH,米国,AMERICAN ASSOCIATION FOR CANCER RESEARCH,2000年10月 1日,V60 N19,P5441-5450
BOIVIN R P,JOURNAL OF MEDICINAL CHEMISTRY,米国,AMERICAN CHEMICAL SOCIETY,2000年,V43 N23,P4465-4478

Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita

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