Title:
エストロゲンレセプター修飾物質
Document Type and Number:
Japanese Patent JP4119246
Kind Code:
B2
Abstract:
The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynacomastia, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer, in particular of the breast, uterus and prostate.
Inventors:
Wilkenning, Robert Earl
Parker, Dan Leroy, Giunia
Wildanger, Kenneth J.A.
Men, Don Juan
Ronald Davrill, Ratcliff
Parker, Dan Leroy, Giunia
Wildanger, Kenneth J.A.
Men, Don Juan
Ronald Davrill, Ratcliff
Application Number:
JP2002544016A
Publication Date:
July 16, 2008
Filing Date:
November 21, 2001
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D209/70; A61K31/403; A61K31/416; A61K31/4184; A61K31/4192; A61P3/00; A61P5/30; A61P5/32; A61P13/08; A61P15/00; A61P15/12; A61P17/10; A61P17/14; A61P19/08; A61P19/10; A61P35/00; A61P43/00; C07D209/56; C07D231/54; C07D231/56; C07D235/02; C07D249/16; C07D401/04; C07D405/04; C07D409/04; A61P5/24
Domestic Patent References:
| JP10067778A |
Other References:
MURATAKE,H. et al.,Total synthesis of marine alkaloids (±)-hapalindoles J and M,Tetrahedron Letters,1989年,Vol.30, No.14,p.1815-1818
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura