ESTROGEN SUBSTANCE BE-26,263 AND PRODUCTION THEREOF

Title:

ESTROGEN SUBSTANCE BE-26,263 AND PRODUCTION THEREOF

Document Type and Number:

Japanese Patent JPH0532658

Kind Code:

A

Abstract:

PURPOSE: To obtain a new compound useful treating gynecological disease, osteoporosis, prostatic carcinoma, prostatic hypertrophy, etc.

CONSTITUTION: A compound shown by the formula. The compound is obtained by culturing a fungus belonging to the genus Scedosporium apiospermum or a variant thereof, fungus F26,263 strain in a nutrient-containing medium under an aerobic condition. Physical and chemical properties BE-26,263. White amorphous solid or crystal. Molecular formula: C38H38O14. Specific rotatory power: [α]D20=-24.3° (C=0.983, methanol). Solubility: soluble in methanol, ethanol, acetone, ethyl acetate and chloroform and insoluble in water and n-hexane. Acidity. Color reaction: positive in potassium permanganate reaction. Strongly antagonizing bond of estrodiol acceptor, showing antagonist activity but not antagonizing bond of progesterone acceptor.

Inventors:

KONDO HISAO
KURAMA MASAE
NAKAJIMA SHIGERU
OSADA KAORI
OKURA AKIRA
SUDA HIROYUKI

Application Number:

JP19106191A

Publication Date:

February 09, 1993

Filing Date:

July 05, 1991

Export Citation:

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Assignee:

BANYU PHARMA CO LTD

International Classes:

A61K31/335; A61K31/357; A61P13/02; A61P15/00; A61P43/00; C07D323/00; C12P17/08; C12R1/645; (IPC1-7): A61K31/335; C07D323/00; C12P17/08

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