ETHYLENEDIAMINE MONOAMIDE DERIVATIVE

Title:

ETHYLENEDIAMINE MONOAMIDE DERIVATIVE

Document Type and Number:

Japanese Patent JPH0273069

Kind Code:

A

Abstract:

NEW MATERIAL: Compounds of formula I [wherein R is formulas II-V; R1 is a phenyl capable of having a substituent (a halogen, alkyl, alkoxy, etc.), dihalophenyl, (halogen) furyl, (halogen) thienyl; R2 is H, a halogen, NH2; R3, R5, R7 are phenyl which can be mono- or di-substituted with a halogen, (halogen) furyl, (halogen thienyl; R4, R6 are H, amino; R8 is H, an alkyl] and their acid addition salts.

EXAMPLE: N-(2-Aminoethyl)-5-phenyl-4-thiazolecarboxamide.

USE: A monoamine oxidase inhibitor with low toxicity, useful for therapy for depression and dysgnosia.

PROCESS: For example, a compound of formula VI, in the form of free acid or a reactive functional derivative, is reacted with ethylenediamine to obtain the compound of the formula I.

More Like This:

JPH05504968	[Title of Invention] A glycinamide derivative, its production, and a pharmaceutical product containing the same.
WO/1988/005435	AROMATIC HETEROCYCLIC CARBOXYLIC ACID AMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME
JPS56123986	PYRROLOBENZOXAZOLE COMPOUND

Inventors:

BARUTAA GASUNAA
RUNE IMUHOFU
EMIRIO KIBURUTSU

Application Number:

JP19282589A

Publication Date:

March 13, 1990

Filing Date:

July 27, 1989

Export Citation:

Click for automatic bibliography generation Help

Assignee:

HOFFMANN LA ROCHE

International Classes:

A61K31/42; A61K31/421; A61K31/425; A61K31/426; A61P25/02; A61P25/24; A61P25/26; C07D231/14; C07D261/18; C07D263/34; C07D263/48; C07D277/20; C07D277/56; C07D413/04; C07D417/04; (IPC1-7): A61K31/42; A61K31/425; C07D231/14; C07D261/18; C07D263/34; C07D263/48; C07D277/56; C07D413/04; C07D417/04

Attorney, Agent or Firm:

Heikichi Odashima

Next Patent: JPH0273070