Title:
リピッドA類縁体含有注射剤の評価方法
Document Type and Number:
Japanese Patent JP3943334
Kind Code:
B2
Abstract:
The present invention provides an evaluation method and preparation process of injection containing a lipid A analog. Specifically, it provides, in an injection preparation containing a lipid A analog or a pharmacologically acceptable salt thereof, forecasting and evaluating methods of the pharmacokinetics of the lipid A analog, and quality evaluating method and preparation process of the injection, which each comprises measuring membrane fluidity and/or circular dichroism.
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Inventors:
Kazuhiro Kaneko
Tomohito Watanabe
Yasuyuki Asai
Yoshitoshi Sano
Kiyomi Kikuchi
Ikuo Kushida
Kazuhide Ashizawa
Tomohito Watanabe
Yasuyuki Asai
Yoshitoshi Sano
Kiyomi Kikuchi
Ikuo Kushida
Kazuhide Ashizawa
Application Number:
JP2000567961A
Publication Date:
July 11, 2007
Filing Date:
August 26, 1999
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
G01N33/92; A61K9/00; A61K31/739; G01N33/15; G01N21/19
Domestic Patent References:
| JP5194470A |
Other References:
Asai, Y., et al.,The effect of divalent cations on the membrane properties and pharmacokinetics in rat of the lipid A analogue E5531,J. Pharm. Pharmacol.,2000年,Vol.52, No.1,p.39-45
Attorney, Agent or Firm:
Satoshi Furuya
Takahiko Mizobe
Shinji Mochida
Yoshitsune Kazumasa
Takahiko Mizobe
Shinji Mochida
Yoshitsune Kazumasa