Title:
新規分子機能の進化
Document Type and Number:
Japanese Patent JP5509270
Kind Code:
B2
Abstract:
Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogues to the amplification of natural biopolymer such as polynucleotides and protein.
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Inventors:
David Earl. Riu
Zev J. Gartner
Matthew W. Canaan
Zev J. Gartner
Matthew W. Canaan
Application Number:
JP2012165977A
Publication Date:
June 04, 2014
Filing Date:
July 26, 2012
Export Citation:
Assignee:
PRESIDENT AND FELLOWS OFHARVARD COLLEGE
International Classes:
C08G85/00; C12N15/09; C07B61/00; C07C231/02; C07C231/12; C07C231/14; C07C233/01; C07C233/64; C07C235/04; C07C237/06; C07C237/20; C07C237/24; C07C237/28; C07C315/04; C07C317/44; C12N15/10; C12P1/00; C12P19/34; C12P21/00; C40B50/06; C12N15/113
Domestic Patent References:
| JP2004536162A | ||||
| JP2001509828A | ||||
| JP2003529328A |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita