To provide a structure for preventing exfoliation of a tile, which enables the tile to be fixed with sufficient adhesion strength to a concrete skeleton, and an exfoliation prevention method using the structure.

An exfoliation prevention structure 7 prevents exfoliation of a plurality of tiles 4 stuck on a concrete skeleton 2 on the basis of joint layout of a straight joint via mortar 3. The exfoliation prevention structure comprises holding members 71 which are each arranged in a vertically passing manner in a position of a vertical longitudinal joint 51 and which collectively hold surface edges of two longitudinal tile rows adjoining each other with the longitudinal joint 51 in between, and anchor means 72 for anchoring the holding member 71 to the concrete skeleton 2 in a part of the longitudinal joint 51.