EXTENDED RECOMBINANT POLYPEPTIDES AND COMPOSITIONS COMPRISING THE SAME

Japanese Patent JP2018076378

A

PROBLEM TO BE SOLVED: To provide compositions and methods useful for enhancing biological, pharmaceutical, safety and/or therapeutic properties of biologically active proteins.SOLUTION: The invention relates to a composition comprising a biologically active protein linked to an extended recombinant polypeptide (XTEN), an isolated nucleic acid encoding the composition and vectors and host cells comprising the nucleic acid, as well as methods for using such a composition for treating glucose-related diseases, metabolic diseases, coagulation disorders and growth hormone-related disorders and symptoms. In one aspect, the invention provides a composition of extended recombinant polypeptide (XTEN), which composition, when linked to a biologically active protein, enhances the pharmacokinetic properties of the obtained fusion protein, and/or increases the solubility and stability of the obtained fusion protein, while enhancing overall biological activity and/or therapeutic activity of the biologically active protein.SELECTED DRAWING: None

VOLKER SCHELLENBERGER
JOSHUA SILVERMAN
WANG CHIA-WEI
BENJAMIN SPINK
STEMMER WILLEM P
NATHAN GEETHING
TO WAYNE
JEFFREY L CLELAND

JP2018017361A

May 17, 2018

February 02, 2018

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AMUNIX OPERATING INC

C07K14/47; A61K38/16; A61K38/20; A61K38/26; A61K38/27; A61K38/36; A61K47/64; A61P1/04; A61P3/04; A61P3/06; A61P3/08; A61P3/10; A61P5/06; A61P7/04; A61P9/00; A61P9/12; A61P19/02; A61P21/04; A61P25/00; A61P25/02; A61P27/02; A61P29/00; C07K14/00; C07K14/475; C07K14/575; C07K19/00; C12N15/09

JP5843357B2

2016-01-13

WO2007103515A2	2007-09-13
WO2008155134A1	2008-12-24

Hidesaku Yamamoto
Natsuki Morishita

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