Title:
感染性病原体又は毒素に関連する疾患のためのワクチンアジュバントとしての細胞外マトリックス物質
Document Type and Number:
Japanese Patent JP2010516763
Kind Code:
A
Abstract:
Disclosed are vaccines and vaccine adjuvants useful in the treatment and/or prevention of infection and diseases associated with infectious pathogens, such as tetanus, as well as diseases associated with biological toxins. Also provided are methods of preparing an adjuvant and the vaccine containing the adjuvant. Methods are also provided for vaccinating/immunizing an animal against infection and diseases associated with infectious pathogens, such as tetanus, and other diseases associated with biological toxins. Adjuvant materials are presented that are prepared from an extracellular matrix material. The adjuvants are demonstrated to enhance the immunogencity of an infectious pathogen antigen or biological toxin antigen of interest, as well as to enhance the survival of an immunized animal.
Inventors:
Mark A Sacco
William Earl Walter
Paul Hall
William Earl Walter
Paul Hall
Application Number:
JP2009547231A
Publication Date:
May 20, 2010
Filing Date:
May 25, 2007
Export Citation:
Assignee:
University of Notre Dame
International Classes:
A61K39/39; A61K39/00; A61K39/008; A61K39/015; A61K39/05; A61K39/08; A61K39/085; A61K39/09; A61K39/145; A61K39/205; A61K39/285; A61K39/29; A61P31/04; A61P39/02; C07K14/78
Domestic Patent References:
| JPH10513363A | 1998-12-22 |
Foreign References:
| US6264992B1 | 2001-07-24 |
Other References:
JPN6012033656; Ｖａｃｃｉｎｅ． １３［７］ （１９９５） ｐ．６５３-６１．
JPN6012033658; Ｊ Ｂｉｏｍｅｄ Ｍａｔｅｒ Ｒｅｓ．， ６７Ａ （１２００３） ｐ．６３７-４０．
JPN6012033652; Ｖａｃｃｉｎｅ． １９［２３-２４］ （２００１） ｐ．３０９１-６．
JPN6012033655; Ｊ Ｂｉｏｍａｔｅｒ Ｓｃｉ Ｐｏｌｙｍｅｒ Ｅｄｎ．， ９［８］ （１９９８） ｐ．８６３-８．
JPN6012033658; Ｊ Ｂｉｏｍｅｄ Ｍａｔｅｒ Ｒｅｓ．， ６７Ａ （１２００３） ｐ．６３７-４０．
JPN6012033652; Ｖａｃｃｉｎｅ． １９［２３-２４］ （２００１） ｐ．３０９１-６．
JPN6012033655; Ｊ Ｂｉｏｍａｔｅｒ Ｓｃｉ Ｐｏｌｙｍｅｒ Ｅｄｎ．， ９［８］ （１９９８） ｐ．８６３-８．
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro