Title:
標的指向性親和性ドメインに基づく膜タンパク質を含む細胞外小胞
Document Type and Number:
Japanese Patent JP7416433
Kind Code:
B2
Abstract:
Disclosed are extracellular vesicles comprising an engineered targeting protein for targeting the extracellular vesicles to target cells. The targeting protein is a fusion protein that includes (i) an affinity agent, such as a single-chain variable fragment of an antibody (scFv), which is expressed on the surface of the extracellular vesicles and (ii) a transmembrane domain, and may include additional domains. Exemplary extracellular vesicles may include but are not limited to exosomes or microvesicles.
Inventors:
Leonard, Joshua, N
Strandford, Devin, M
Strandford, Devin, M
Application Number:
JP2020555922A
Publication Date:
January 17, 2024
Filing Date:
April 10, 2019
Export Citation:
Assignee:
Northwestern University
International Classes:
C12N15/62; C12N5/10; C12N15/63; C12N15/88
Domestic Patent References:
| JP2021508691A |
Foreign References:
| US20170087087 | ||||
| WO2015002956A1 | ||||
| US20150057191 | ||||
| US20150093433 | ||||
| WO2017134100A1 |
Attorney, Agent or Firm:
Patent Attorney Corporation Xie International Patent and Trademark Office