PURPOSE: To extract and separate the titled compound, by adding an aqueous solution of trimethylamine hydrochloride to a mixture containing an optically active ester and halogenomethyloxirane under specific condition, selectively converting only one thereof into an alcohol derivative and extracting and separating the titled compound with a hydrophobic organic solvent.
CONSTITUTION: An aqueous solution of trimethylamine hydrochloride is added to a mixture containing an optically active ester expressed by formula I (X is halogen; R is 1W8C aliphatic hydrocarbon; R' is aromatic hydrocarbon) and an optically active halogenmethyloxirane expressed by formula III to selectively react only the compound expressed by formula II and form a compound expressed by formula III. After completing the reaction, the compound expressed by formula I is extracted and compound expressed by formula I and the compound expressed by formula III with a hydrophobic organic solvent, e.g. methylene chloride, and the organic solvent layer is concentrated to collect the compound expressed by formula I. The other aqueous layer is then concentrated to collect the compound, expressed by formula III and useful as an important intermediate for synthesizing l-carnitine.
| WO/2001/004336 | METHOD OF REDUCING KETO-CARBOXYLIC ACIDS AND THEIR ESTERS |
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KOBAYASHI MAKOTO
KATAYAMA KAZUHIKO
OHASHI TAKEHISA
WATANABE KIYOSHI
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