Title:
押出成形された持続放出性乱用抑止性丸剤
Document Type and Number:
Japanese Patent JP6403780
Kind Code:
B2
Abstract:
The present disclosure relates to an oral, extended release, abuse deterrent pill containing at least one active pharmaceutical ingredient susceptible to abuse which is homogeneously spread throughout a matrix used to deter abuse. The pill can be prepared using a hot melt extrusion process and a forming unit. The formed pill meets regulatory guidelines for extended release formulations and is abuse deterrent to parenteral administration due at least to particle size, viscosity, or purity limitations.
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Inventors:
Thompson, Edwin, Earl.
Thompson, Eric, Earl.
Misrinski, Nicholas, Earl.
Kemeny, Stephen, F.
Thompson, Eric, Earl.
Misrinski, Nicholas, Earl.
Kemeny, Stephen, F.
Application Number:
JP2016540580A
Publication Date:
October 10, 2018
Filing Date:
December 17, 2014
Export Citation:
Assignee:
Pharmaceutical Manufacturing Research Services, Inc.
International Classes:
A61K47/10; A61K9/20; A61K31/135; A61K31/485; A61K45/00; A61K47/04; A61K47/12; A61K47/22; A61K47/24; A61K47/32; A61K47/38; A61P25/04
Domestic Patent References:
| JP2008504327A |
Foreign References:
| WO2014006004A1 | ||||
| US20130280176 |
Other References:
TREFFER, D., et al.,Pellet Production by Hot Melt Extrusion and Die Face Pelletising,Pharmaceutical Solid State Research Cluster,2013年 5月 7日,URL,http://www.pssrc.org/component/k2/89
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Naotoshi Ikeda
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Naoko Kikuta
Naotoshi Ikeda