PURPOSE: To provide clear eye drops of sulfa drug, resistant remarkably to discoloration, by adding a reducing sulfate and a hydrophilic nonionic surface active agent to eye drops containing a sulfa drug and glycyrrhizic acid or its salt.
CONSTITUTION: A reducing sulfate (e.g. sodium sulfite, potassium sulfite, etc.) and a hydrophilic nonionic surface active agent (e.g. polyoxyethylene sorbitan monooleate) are added to eye drops containing a sulfa drug (e.g. sulfamethoxazole) and glycyrrhizic acid or its salt. The preferable amount of the reducing sulfate is 0.02W0.2%(W/V) and that of the hydrophilic nonionic surface active agent is 0.05W0.2%(W/V). Eye drops having extremely high resistance to discoloration and storable for a long period without causing color development can be obtained by the combined use of a reducing sulfate and a hydrophilic nonionic surface active agent.
YOKOO TAKAO
SHINOZAKI YUKIKO
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