Title:
エゼチミベ多形体
Document Type and Number:
Japanese Patent JP2007526251
Kind Code:
A
Abstract:
Provided are processes for preparing crystalline forms of ezetimibe, such as ezetimibe Form A or Form B, for example, by precipitating ezetimibe from selected solvents. Alternatively, some forms may be transformed into different forms at elevated temperatures or under various humidity conditions, or by micronization. Also provided are micronized ezetimibe Form A, micronized ezetimibe Form B, and ezetimibe having a plate morphology. Pharmaceutical compositions containing these forms are particularly useful in reducing cholesterol in patients in need thereof.
Inventors:
Aronheim, Judith
Coltai, Tamas
Samburski, Guy
Railman, oli
Issaku, Reuben
Coltai, Tamas
Samburski, Guy
Railman, oli
Issaku, Reuben
Application Number:
JP2006552381A
Publication Date:
September 13, 2007
Filing Date:
December 05, 2005
Export Citation:
Assignee:
Teva Pharmaceutical Industries Limited
International Classes:
C07D205/08; A61K9/16; A61K31/397; A61P3/06
Foreign References:
| WO2005009955A1 | 2005-02-03 | |||
| WO2004099132A2 | 2004-11-18 | |||
| US5886171A | 1999-03-23 | |||
| US6207822B1 | 2001-03-27 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura
Takashi Ishida
Fukumoto product
Tetsuji Koga
Kazuhiro Nakamura