Title:
FGFR結合性ペプチド
Document Type and Number:
Japanese Patent JP2008504236
Kind Code:
A
Abstract:
The present invention relates to new peptide compounds capable of direct binding to fibroblast growth factor receptor (FGFR) and activating said receptor. The compounds of the invention comprise peptide fragments of the neural cell adhesion molecule (NCAM) derived from the fibronectin type-III module 1 (F3, 1) of NCAM. Peptide sequences of the invention are capable of stimulating learning and memory and/or neurite outgrowth and/or neural cell survival. Peptide sequences and compounds comprising thereof, according to the invention, may be beneficially used for treatment and/or prevention of different pathological conditions wherein FGFR and/or NCAM play a role in pathology and/or recovery from disease. Accordingly, pharmaceutical compositions comprising the peptide sequences and compounds of the invention are also in the scope of protection.
Inventors:
Elisabeth Bock
Vladimir Beresin
Vladimir Beresin
Application Number:
JP2007515781A
Publication Date:
February 14, 2008
Filing Date:
June 17, 2005
Export Citation:
Assignee:
Encome Pharmaceuticals Actiesel Scab
International Classes:
C07K14/78; A61K38/00; A61K39/395; A61P25/14; A61P25/16; A61P25/18; A61P25/28; A61P35/00; C07K7/00; C07K14/705; C07K16/28
Domestic Patent References:
| JP2005510463A | 2005-04-21 |
Foreign References:
| WO2003016351A2 | 2003-02-27 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Takuji Yamada
Mitsutaka Iwasaki
Takuji Yamada
Mitsutaka Iwasaki