Title:
免疫抑制活性なしに神経再生活性が維持されるＦＫ５０６誘導体及びその用途
Document Type and Number:
Japanese Patent JP6370490
Kind Code:
B2
Abstract:
The present invention relates to an FK506 derivative which has reduced immunosuppressive activity but maintains nerve regeneration activity, a preparing method thereof, and a pharmaceutical composition comprising the same for preventing or treating nervous system diseases. A composition comprising 9-deoxo-prolyl-FK506, 31- O -demethyl-FK506, or 9-deoxo-31- O -demethyl-FK506 can promote nerve regeneration and has reduced immunosuppressive activity, thereby reducing side effects in the treatment of nervous system diseases.
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Inventors:
Jeo Jeon Jeon
Hojeong Kuon
Yeon Hee Bang
Cinde Pramodov
Hojeong Kuon
Yeon Hee Bang
Cinde Pramodov
Application Number:
JP2017526030A
Publication Date:
August 08, 2018
Filing Date:
July 31, 2015
Export Citation:
Assignee:
Intron Biotechnology C.O., LDT
International Classes:
A61K31/7056; A61P25/00; C07H9/06; C12P19/26
Foreign References:
| US4894366 | ||||
| US20090325906 |
Other References:
Expert. Opin. Investig. Drugs,2000年10月,Vol.9, No.10,p.2331-2342
The Journal of Antibiotics,1997年 5月,Vol.50, No.5,p.418-423
Journal of Natural Products,2013年,Vol.76,p.1091-1098
J. Bacteriol., 2013, Vol.195, No.9, pp.1931-1939
RSC Advances,2014年12月18日,Vol.5,pp.6823-6828,DOI:10.1039/C4RA11907J
The Journal of Antibiotics,1997年 5月,Vol.50, No.5,p.418-423
Journal of Natural Products,2013年,Vol.76,p.1091-1098
J. Bacteriol., 2013, Vol.195, No.9, pp.1931-1939
RSC Advances,2014年12月18日,Vol.5,pp.6823-6828,DOI:10.1039/C4RA11907J
Attorney, Agent or Firm:
Toru Ishikawa