Fab glycosylation antibody - Glicotope Game Behr

Title:

Fab glycosylation antibody

Document Type and Number:

Japanese Patent JP6334166

Kind Code:

B2

Abstract:

The present invention pertains to a method for controlling the circulation half-life of antibodies by adjusting the amount of sialic acid in the carbohydrates attached to the Fab part of the antibodies. Furthermore, the present invention provides antibodies having an increased circulation half-life.

Inventors:

Goletts, Steffen
Daniel Chik, Anche
Steckle, Lars

Application Number:

JP2013523612A

Publication Date:

May 30, 2018

Filing Date:

August 10, 2011

Export Citation:

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Assignee:

Glicotope Game Behr

International Classes:

C12N15/09; A61K39/395; C07K16/18; C07K16/46

Domestic Patent References:

JP2010502204A
JP2009504569A
JP7506339A

Foreign References:

WO2008028686A2
WO2005016455A2
WO2008101177A2
WO2007034210A2
WO2003016466A2
WO2003074679A2
WO2004065423A2
WO2006125207A2
WO2009126564A2
WO2009149185A2
WO1995015769A1

Other References:

BIOCONJUGATE CHEMISTRY、2008.03.01、Vol.19、 No.3、p.643-650
DRUG DISCOVERY TODAY、2007.03.27、Vol.12、 No.7-8、p.319-326
CANCER BIOTHERAPY & RADIOPHARMACEUTICALS、2000.、Vol.15、 No.5、p.507-515
JOURNAL OF IMMUNOLOGY、1995.、Vol.154、 No.11、p.5919-5926
THE EMBO JOURNAL、英国、1991.10.01、Vol.10 No.10、p.2717-2723
MOLECULAR IMMUNOLOGY、1995.、Vol.32、No.13、p.931-940
The Journal of Biological Chemistry、2008.、Vol.283,No.12、p.7804-7812
Clinical Cancer Research、1999.、Vol.5、3106s-3117s

Attorney, Agent or Firm:

Hidesaku Yamamoto
Natsuki Morishita

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