Title:
第Xa因子のラクタム系阻害剤および方法
Document Type and Number:
Japanese Patent JP2004512267
Kind Code:
A
Abstract:
Lactam inhibitors are provided which have the structureincluding pharmaceutically acceptable salts thereof and all stereoisomers thereof, and prodrug esters thereof, wherein n is 1 to 5; andand R1, R2, R3, R4, R5 , R6, R7, R8, R9, R10, R10a, R11 and R12 are as defined herein. These compounds are inhibitors of Factor Xa and thus are useful as anticoagulants. A method for treating cardiovascular diseases associated with thromboses is also provided.
Inventors:
Philip De Stein
Yang Shi
Steven Pee O'Connor
Chile
Yang Shi
Steven Pee O'Connor
Chile
Application Number:
JP2002510473A
Publication Date:
April 22, 2004
Filing Date:
June 07, 2001
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/4025; A61K31/454; A61K31/55; A61K31/663; A61P3/06; A61P3/10; A61P5/00; A61P7/02; A61P7/10; A61P9/04; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P15/18; A61P19/10; A61P25/24; A61P29/00; A61P43/00; C07D223/10; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/12; C07D405/14; C07D409/12; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D223/12; C07D417/14; (IPC1-7): C07D223/12; A61K31/4025; A61K31/454; A61K31/55; A61K31/663; A61P3/06; A61P3/10; A61P5/00; A61P7/02; A61P7/10; A61P9/04; A61P9/06; A61P9/08; A61P9/10; A61P9/12; A61P11/00; A61P15/18; A61P19/10; A61P25/24; A61P29/00; A61P43/00; C07D401/12; C07D401/14; C07D403/12; C07D403/14; C07D405/12; C07D405/14; C07D409/14; C07D413/12; C07D413/14; C07D417/12; C07D417/14
Attorney, Agent or Firm:
Aoyama Aoi
Osamu Kawamiya
Kyousei Tamura
Misako Ohsaku
Osamu Kawamiya
Kyousei Tamura
Misako Ohsaku