Title:
免疫調節活性および化学防護活性を有する置換型プリニル誘導体ならびにその単独使用または中鎖長の脂肪酸もしくはグリセリドとの併用
Document Type and Number:
Japanese Patent JP2008511553
Kind Code:
A
Abstract:
The present invention describes new biological activities of immunomodulating 6-substituted purinyl compounds which make them particularly useful during the treatment of cancer. Collectively, these new biological activities make these purinyl compounds useful chemoprotective agents for the treatment of myelosuppression which is associated with cancer chemotherapy and/or radiotherapy. This chemoprotective activity is in addition to the immunomodulating and subsequent anticancer activity displayed by these compounds. The chemoprotective usefulness of these compounds is further enhanced by the use of medium-chain fatty acids or salts or triglycerides or mono- or diglycerides in combination with the 6-substituted purinyl compounds of this invention.
Inventors:
Penny, christopher
The Cali, Bouros
Barabé, Jean
Laurent, Pierre
Ganyon, line
The Cali, Bouros
Barabé, Jean
Laurent, Pierre
Ganyon, line
Application Number:
JP2007528546A
Publication Date:
April 17, 2008
Filing Date:
September 02, 2005
Export Citation:
Assignee:
Prometric Biosciences, Inc.
International Classes:
A61K31/52; A61K31/20; A61K31/417; A61P7/00; A61P7/06; C07D473/34; A61K31/23
Attorney, Agent or Firm:
Yusuke Hiraki
Ishii Teiji
Satoshi Fujita
Ishii Teiji
Satoshi Fujita