Title:
Ｆｃ領域改変体
Document Type and Number:
Japanese Patent JP7157031
Kind Code:
B2
Abstract:
A polypeptide containing an antibody Fc region variant which has an amino acid sequence in which an amino acid alteration at position 238 according to EU numbering is combined with other specific amino acid alteration(s), was found to have decreased binding activities to all activating FcγRs, in particular FcγRIIa (R type), while maintaining its FcγRIIb-binding activity, when compared to a polypeptide containing a native IgG Fc region.
Inventors:
Futa Ajimoto
Hitoshi Katsuta
Tomoyuki Ikawa
Hitoshi Katsuta
Tomoyuki Ikawa
Application Number:
JP2019181333A
Publication Date:
October 19, 2022
Filing Date:
October 01, 2019
Export Citation:
Assignee:
Chugai Pharmaceutical Co., Ltd.
International Classes:
C07K16/28; A61K38/16; A61K39/395; A61P37/02; C07K16/00; C07K16/42; C07K19/00
Foreign References:
| WO2012115241A1 | ||||
| WO2009125825A1 | ||||
| WO2012133782A1 | ||||
| WO2012132067A1 |
Other References:
The Journal of Immunology,2000年,Vol.164,p.4178-4184
Attorney, Agent or Firm:
Masao Haruna
Shimizu Hatsushi
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Kousuke Umemura
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Maki Shioda
Kazuya Kawamoto
Shimizu Hatsushi
Hirotaka Yamaguchi
Shun Jinbe
Ryuichi Inoue
Toshimitsu Sato
Kousuke Umemura
Koichi Niimi
Tomohiko Kobayashi
Hideki Kodera
Masato Ozeki
Maki Shioda
Kazuya Kawamoto