フェロセニル配位子、製造およびその使用

Japanese Patent JP2008540377

A

The invention relates to the compounds of formula (I) in the form of enantiomer-pure diastereomers or a mixture of diastereomers, wherein R'1 represents C1-C4 alkyl, C6-C10 aryl, C7-C10 alkyl or C7-C12 alkaralkyl and n is 0 or an integer of from 1 to 5; R1 represents a hydrogen atom, halogen, a hydrocarbon group with 1 to 20 C atoms that is either unsubstituted or substituted with -SC1-C4 alkyl, -OC1-C4 alkyl, -OC6-C10 aryl or -Si(C1C4 alkyl)3, or a silyl group with 3 C1-C12 hydrocarbon groups; Y represents vinyl, methyl, ethyl, -CH2-OR, -CH2-N(C1-C4 alkyl)2, a C-bound chiral group that directs metals of metallation reagents to the ortho position X1, or Y is a group -CHR2-OR'2; R2 represents C1-C8 alkyl, C5-C8 cycloalkyl, C6-C10 aryl, C7-C12 aralkyl or C7-C12 alkaralkyl; R'2 represents hydrogen or C1-C18 acyl; X1 and X2 independently represent a P-bound P(III) substituent, -SH or an S-bound group of mercaptan; and R represents hydrogen, a silyl group or an aliphatic, cycloaliphatic, aromatic or aromatic-aliphatic hydrocarbon group with 1 to 18 C atoms which is unsubstituted or substituted with C1-C4 alkyl, C1-C4 alkoxy, F or CF3. The inventive compounds are ligands for metal complexes of transition metals such as Ru, Rh or Ir which are catalysts for especially the enantioselective hydration of prochiral unsaturated compounds. Use of these compounds allows to achieve high catalyst activities and an excellent stereoselectivity.

Pujan, Benoit
Fen, Xianton

JP2008509435A

November 20, 2008

May 02, 2006

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Solvias AG

C07F17/02; B01J31/24; C07C51/36; C07C57/30; C07C67/303; C07C69/34; C07C213/02; C07C217/08; C07C231/12; C07C233/47; C07F19/00; C07B53/00; C07B61/00; C07F9/50; C07F9/655; C07F15/00; C07F15/02

Hajime Tsukuni
Koshiro Tsukuda
Fusayuki Saito

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