Title:
FINE PARTICLE CONTAINING BIODEGRADABLE POLYMER FOR CONTROLLING RELEASE OF ANTIMALARIAL EFFECTIVE COMPONENT, MEDICINAL COMPOSITION AND MANUFACTURE
Document Type and Number:
Japanese Patent JPS6442433
Kind Code:
A
Abstract:
PURPOSE: To prepare a medicinal composition, comprising primaquine (derivative) as an active ingredient in a biodegradable polymer and capable of controlling the release of the active ingredient and prolonging the duration of actions. CONSTITUTION: This fine particle comprises an active ingredient, selected from among primaquine(PQ), a derivative represented by the formula PQ-X (X is an amino acid or a peptide having 2-4 amino acids; PQ-X bond is a peptide bond between free amino groups in the PQ to carboxyl groups of X) or a conjugate of the PQ or PQ-X with a hepatotropic vector and distributed in a matrix of a polylactide polymer, preferably the -form (having 10,000-200,000, preferably 50,000-100,000 molecular weight). The weight ratio of the active ingredient/ polymer is 1-50%, preferably 15-25%. The particle size is 1-250μm, preferably 100-200μm and prescribed for a solution for parenteral injection.
Inventors:
JIYOZE BONTEN
FUIRITSUPU PIRUSON
JIYANNBERUNAARU FUARUMAAJIYU
ROBERUTO JIYOROMU
FUIRITSUPU TEISHII
RIYUKU DERATOURE
BURIJITSUTO EBURARUDO
FUIRITSUPU PIRUSON
JIYANNBERUNAARU FUARUMAAJIYU
ROBERUTO JIYOROMU
FUIRITSUPU TEISHII
RIYUKU DERATOURE
BURIJITSUTO EBURARUDO
Application Number:
JP18852088A
Publication Date:
February 14, 1989
Filing Date:
July 29, 1988
Export Citation:
Assignee:
II R EE SERUTAARUKU SA
International Classes:
A61K9/16; A61K9/22; A61K9/62; A61K9/64; A61K31/47; A61K47/48; A61P33/02; (IPC1-7): A61K9/64; A61K31/47; A61K47/00
Attorney, Agent or Firm:
Masao Okabe (5 others)
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