Title:
微粒子含有組成物およびその製造方法
Document Type and Number:
Japanese Patent JP4884975
Kind Code:
B2
Abstract:
The present invention provides a composition containing fine particles of a hardly-soluble drug which is stable and is not affected by storage environment conditions, as well as a manufacturing method therefor. The present invention provides a fine particle-containing composition containing fine particles of the hardly-soluble drug, a surfactant and a cyclic oligosaccharide, wherein an average particle size of the fine particles is at least 50 nm but not more than 1000 nm. The present invention also provides a method for manufacturing a fine particle-containing composition, comprising (I) a mixing step in which the hardly-soluble drug, the surfactant and a poor solvent are mixed to obtain a liquid mixture, (II) a pulverization step in which the liquid mixture is pulverized with a wet disperser to obtain a dispersion of fine particles, (III) an addition step in which the cyclic oligosaccharide is added to the dispersion of fine particles, and (IV) a drying step in which the dispersion of fine particles containing the cyclic oligosaccharide is dried.
Inventors:
Yousuke Ueki
Application Number:
JP2006539262A
Publication Date:
February 29, 2012
Filing Date:
September 30, 2005
Export Citation:
Assignee:
Eisai R & D Management Co., Ltd.
International Classes:
A61K47/36; A61K9/14; A61K9/16; A61K47/40; A61K31/64; A61P3/10
Domestic Patent References:
| JP2006500387A | 2006-01-05 | |||
| JP2005533078A | 2005-11-04 | |||
| JP2002504526A | 2002-02-12 |
Foreign References:
| WO2004022100A1 | 2004-03-18 |
Attorney, Agent or Firm:
Yoshiyuki Inaba
Katsuro Tanaka
Shinji Oga
Toshifumi Onuki
Katsuro Tanaka
Shinji Oga
Toshifumi Onuki