Title:
MONOAMINEOXIDASE INHIBITOR
Document Type and Number:
Japanese Patent JP3228671
Kind Code:
B2
Abstract:
PROBLEM TO BE SOLVED: To obtain a therapeutic medicine or preventing medicine for nerve diseases such as Parkinson's disease, containing a specific isoxazole derivative as an active ingredient, having excellent monoamine oxidase inhibiting action and weak toxicity.
SOLUTION: This isoxazole derivative is represented by formula I [R1 is H, a halogen, an alkyl, an alkoxy, OH, an alkylthio, amino, etc.; R2a is amino, a (di)alkylamino or a 5-6 membered heterocyclic ring; (m) is 1-3; (n) is 1-6; ring A is phenyl ring, naphthyl ring or heterocyclic ring cyclicly condensed with isoxazole; X is O or S] or its pharmacologically permissible salt. Especially 3-(2-aminoethoxy)benzoisoxazole, 3-(2-aminoethoxy)pyrido[3,2-d]isoxazole is preferably used as the compound of formula I. The compound of formula I is obtained by passing through 5 steps from a compound of formula II (R3 is an ester residue).
Inventors:
Koichi Kojima
Junichi Sakai
Naozumi Sabure
Kazuo Koyama
Masao Kitsunezuka
Kenji Yoshimi
Isao Kaneko
Yuichi Aizawa
Junichi Sakai
Naozumi Sabure
Kazuo Koyama
Masao Kitsunezuka
Kenji Yoshimi
Isao Kaneko
Yuichi Aizawa
Application Number:
JP3981896A
Publication Date:
November 12, 2001
Filing Date:
February 27, 1996
Export Citation:
Assignee:
Sankyo Co., Ltd.
International Classes:
C12N9/99; A61K31/42; A61K31/423; A61K31/435; A61K31/445; A61K31/535; A61K31/5377; A61P25/00; A61P25/16; A61P25/24; A61P25/26; A61P25/28; A61P43/00; C07D261/20; C07D498/04; C07D513/04; (IPC1-7): C07D261/20; A61K31/423; A61K31/435; A61K31/445; A61K31/535; A61P25/16; A61P25/24; A61P25/28; C07D498/04; C07D513/04
Domestic Patent References:
| JP476302B2 |
Attorney, Agent or Firm:
Akio Ohno (1 outside)