Title:
フッ素化胆汁酸誘導体
Document Type and Number:
Japanese Patent JP2021533206
Kind Code:
A
Abstract:
一般式(I)の化合物:【化１】(式中、R2a、R2b、R3a、R3b、R5、Y及びR7は明細書に規定されている)は、FXR受容体の選択的なアゴニストであり、非アルコール性脂肪性肝炎(NASH);原発性胆汁性肝硬変;原発性硬化性胆管炎;胆道閉鎖症;胆汁鬱滞性肝疾患;C型肝炎感染症;アルコール性肝疾患;線維症;又は線維症から生じる肝障害を含む、疾患及び症状の治療又は予防に有用である。【選択図】なし
Inventors:
Alexander Charles Weymouth-Wilson
Gema Packer
Bruno Jean Pollinklau
Daniel Kid-Sinclair
Kimberly Ann Watson
Gema Packer
Bruno Jean Pollinklau
Daniel Kid-Sinclair
Kimberly Ann Watson
Application Number:
JP2021529531A
Publication Date:
December 02, 2021
Filing Date:
July 30, 2019
Export Citation:
Assignee:
N.P.P.U.K.Limited
The University of Southampton
The University of Southampton
International Classes:
C07J41/00; A61K31/575; A61P1/00; A61P1/16; A61P13/12; A61P31/12; A61P43/00
Attorney, Agent or Firm:
Toru Ishikawa
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