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Title:
フッ素化トリペプチドHCVセリンプロテアーゼ阻害剤
Document Type and Number:
Japanese Patent JP2011517655
Kind Code:
A
Abstract:
The present invention relates to compounds of Formula I, or a pharmaceutically acceptable salt, ester, or prodrug, thereof: which inhibit serine protease activity, particularly the activity of hepatitis c virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis c virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

Inventors:
Guy, Yonghua
Oa, Yatto Seung
One, Jia
Application Number:
JP2010537077A
Publication Date:
June 16, 2011
Filing Date:
December 04, 2008
Export Citation:
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Assignee:
Enanta Pharmaceuticals, Inc.
International Classes:
C07K5/08; A61K38/55; A61K45/00; A61P31/12; A61P31/14; A61P43/00; C07K5/10; C12N9/99
Domestic Patent References:
JP2005533028A2005-11-04
JP2007534636A2007-11-29
JP2002522554A2002-07-23
Attorney, Agent or Firm:
Kawaguchi International Patent Office