神経保護性の及び認知を向上させる性質を備えた水素化されたピリド[4,3-b]インドール類のフッ素を含有する誘導体、調製するための工程、並びに使用

Japanese Patent JP2010540439

A

Some exemplary embodiments comprise fluoro-containing derivatives of pyrido[4,3-b]indoles (and exemplary methods of making the same) that may be administered to a mammal (including a human) in an effective amount for potential use in the treatment or prophylaxis of neurological disorders including AD, mild cognitive impairment, senile and vascular dementia, HD, ALS, Parkinson's disease, AIDS-related dementia, ischaemic cerebral pathologies, neuropathic pain, ADHD (attention deficit disorder/hyperactivity syndrome), eating disorders such as anorexia and bulimia, panic attacks, withdrawal from drug abuse such as cocaine, ethanol, nicotine and benzodiazepines, schizophrenia (in particular the cognitive deficit of schizophrenia), stroke and also disorders associated with spinal trauma and/or head injury. These derivatives may also be useful for the treatment of borderline personality disorder, obesity, and for use as geroprotectors. The compounds may also be used as “pharmacological tools” for an investigation of the mechanism of protection against neurodegeneration disorders in vivo or in vitro.

WO/2015/153720	BIARYL KINASE INHIBITORS
WO/1995/014672	ISOXAZOLE AND PYRAZOLE DERIVATIVES AS DOPAMINE RECEPTOR SUBTYPE LIGANDS

Sabrin, Sir Jay
Batulin
Beznosco, Be
Sokolov, V
Aksinenko, Ah

JP2010525836A

December 24, 2010

September 19, 2008

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D2y, LRC

C07D471/04; A61K31/13; A61K31/444; A61K31/445; A61K45/00; A61P1/14; A61P3/04; A61P9/00; A61P9/10; A61P21/00; A61P21/04; A61P25/00; A61P25/04; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P25/32; A61P25/34; A61P25/36; A61P31/18; A61P43/00

Tadahiko Ito
Shinsuke Onuki
Tadashige Ito

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