To obtain the subject compound expressed by a specific formula in which hydroxyl group at 2-position of fucose is chemically modified with fluorine, suppressing neutrophils-depended diseases and selectin-dependent acute inflammation and useful for treating and preventing thrombogenesis, asthma rheumatism, etc.

This compound is expressed by the formula [R is a 2-6C aliphatic acyl; R1 is H or a 1-5C alkyl; R20, R30 and R5 are each H, a 2-6C aliphatic or a 7-13C aromatic acyl; R4 is OH, a 2-6C aliphatic or a 7-13 aromatic acylamino or an acyloxy; Ra is a 1-30C aliphatic hydrocarbon; Me is methyl; (n) is 0-20], {e.g. 0-(5-acetamide-3,5-dideoxy-D-glycero-2-D-galacto-2- nonyuropyranosylonic acid)-(2→3)-O-β-D-galactopyranosyl-(1→4)-0-[(2-deoxy-2- fluoro-α-L-fucopyranosyl)-(1→3)]-0-(2-acetamide-2-deoxy-β-D- glucopyranosyl)-(1→3)]-0-β-D-galactopyransoyl-(1→4)-β-D-glucopyranosyl-(1→1)-(2S, 3R, 4E)-2-tetracosanamide-4-octabecene-1,3-diol, etc.