Title:
FLUORINE-CONTAINING VITAMIN D DERIVATIVE
Document Type and Number:
Japanese Patent JPS63196556
Kind Code:
A
Abstract:
NEW MATERIAL:The compound of formula I (R1 is methyl or trifluoromethyl; R2 is trifluoromethyl when R1 is methyl or R2 is methyl when R1 is trifluoromethyl).
EXAMPLE: 26,26,26,27,27,27-Hexafluoro-25-hydroxyvitamin D3.
USE: Useful as a drug having vitamin D3-like activity.
PREPARATION: The compound of formula I (R1 is CF3 and R2 is CH3) can be produced according to the reaction formula by reacting the compound of formula CH3CH2CO2Et (Et is ethyl) with lithium cyclohexyl isopropylamide, CF3COCF3, etc., and reacting the resultant compound of formula 2 with the compound of formula ClCH2OCH3.
Inventors:
KOBAYASHI YOSHIRO
TAGUCHI TAKEO
IKEGAWA NOBUO
TAGUCHI TAKEO
IKEGAWA NOBUO
Application Number:
JP2942387A
Publication Date:
August 15, 1988
Filing Date:
February 10, 1987
Export Citation:
Assignee:
TAISHO PHARMACEUTICAL CO LTD
International Classes:
A61P5/38; A61P13/02; A61K31/59; A61P15/00; A61P43/00; C07C67/00; C07C401/00; C07J9/00; C07J17/00; C07J31/00; (IPC1-7): A61K31/59; C07C172/00
Attorney, Agent or Firm:
Kitagawa Fuzo