Title:
フルオロアルキル-及びフルオロアルコキシ-置換複素環ブラジキニンアンタゴニスト、それらの製造法及びそれらの使用
Document Type and Number:
Japanese Patent JP4199315
Kind Code:
B2
Abstract:
Fluoroalkyl- and fluoroalkoxy-substituted benzyloxy-azaheterocyclic compounds of formula (I) and their salts are new: X1-X3 = N or CR<5>; R<1>, R<2> = H or halo; R<3>, R<4> = H, halo, 1-5C alkyl or 2-5C alkenyl; R<5> = 2-5C alkenediyl, halo, OR<6>, SR<6>, NHR<6>, -COOR<6> or COOH; 1-6C alkyl, 6-12C aryl or 6-12C aryl-1-3C alkyl (all optionally substituted by e.g. OR<6>, SR<6>, NO2, CN, NHR<6> or halo); R<6>, R<8> = H, 1-5C alkyl, 3-5C alkenyl or 6-12C aryl-1-3C alkyl; R<7> = 1-5C alkyl or 1-5C alkoxy (both substituted by 1 or more F or Cl); B = amino acid; D = 2-5C alkanediyl, 1-5C alkanediyl or -(CH2)n-Yp-(CH2)m-; E = O or S; Y = O, S or NR<8>; n, m = 0-3; o = 1-3; and p = 0 or 1.
Inventors:
Adalbert Wergner
Holger Haitiyu
Gerhard Nerken
Klaus Wylt
Bernve Alt Sierkens
Holger Haitiyu
Gerhard Nerken
Klaus Wylt
Bernve Alt Sierkens
Application Number:
JP6474897A
Publication Date:
December 17, 2008
Filing Date:
March 18, 1997
Export Citation:
Assignee:
Hoechst Gesellschaft Mito Beschlenktel Haftung
International Classes:
C07D215/26; A61K31/345; C07D237/28; A61K31/47; A61K31/495; A61K31/53; A61P29/00; A61P37/00; A61P43/00; C07D215/04; C07D239/72; C07D239/74; C07D241/36; C07D241/44; C07D253/04; C07D253/065; C07D257/10
Domestic Patent References:
| JP7002780A |
Other References:
石川延男,小林義郎,フッ素の化合物-その化学と応用,株式会社講談社,1979年,p.202-212
Attorney, Agent or Firm:
Chika Takagi
Tatsuo Sato
Kosuke Nishimura
Tatsuo Sato
Kosuke Nishimura