Title:
酸化ストレス障害を処置するためのフルオロアルキル、フルオロアルコキシ、フェノキシ、ヘテロアリールオキシ、アルコキシ、およびアミノ１，４−ベンゾキノン誘導体
Document Type and Number:
Japanese Patent JP6905527
Kind Code:
B2
Abstract:
Disclosed herein are compounds and methods of using such compounds for treating or suppressing oxidative stress disorders, including mitochondrial disorders, impaired energy processing disorders, neurodegenerative diseases and diseases of aging, or for modulating one or more energy biomarkers, normalizing one or more energy biomarkers, or enhancing one or more energy biomarkers, wherein the compounds are tocopherol quinone derivatives. Further disclosed are compounds, compositions, and methods for treatment of, or prophylaxis against, radiation exposure.
Inventors:
Hinman, Andrew W.
Richards, Stephen Jay.
Richards, Stephen Jay.
Application Number:
JP2018531554A
Publication Date:
July 21, 2021
Filing Date:
December 17, 2016
Export Citation:
Assignee:
PTC Therapeutics, Incorporated
International Classes:
C07C50/04; A61K31/122; A61K31/13; A61K31/18; A61K31/40; A61K31/44; A61P3/00; A61P3/02; A61P3/10; A61P7/06; A61P9/00; A61P9/10; A61P13/12; A61P21/00; A61P21/04; A61P25/00; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/28; A61P27/02; A61P27/06; A61P27/16; A61P35/00; A61P39/00; A61P39/06; A61P43/00; C07C50/28; C07C225/28; C07C311/08; C07D207/08; C07D213/65
Domestic Patent References:
| JP2009527567A | ||||
| JP2015533794A | ||||
| JP8239340A |
Foreign References:
| WO2012022467A1 |
Other References:
DUVEAU, D. Y. et al.,Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria,BIOORGANIC & MEDICINAL CHEMISTRY,2010年,Vol.18, No. 17,pp.6429-6441
OKAMOTO, K. et al.,Effects of 6-(ω-substituted alkyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinones and related compounds on mitochondrial succinate and reduced nicotinamide adenine dinucleotide oxidase systems,Chemical & Pharmaceutical Bulletin ,1985年,Vol.33, No.9,pp.3745-3755
LIU, Jian-Bo et al.,Silver-Mediated Oxidative Trifluoromethylation of Alcohols to Alkyl Trifluoromethyl Ethers,Organic Letters,2015年,Vol.17, No.20,pp.5048-5051
OKAMOTO, K. et al.,Effects of 6-(ω-substituted alkyl)-2,3-dimethoxy-5-methyl-1,4-benzoquinones and related compounds on mitochondrial succinate and reduced nicotinamide adenine dinucleotide oxidase systems,Chemical & Pharmaceutical Bulletin ,1985年,Vol.33, No.9,pp.3745-3755
LIU, Jian-Bo et al.,Silver-Mediated Oxidative Trifluoromethylation of Alcohols to Alkyl Trifluoromethyl Ethers,Organic Letters,2015年,Vol.17, No.20,pp.5048-5051
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto
Natsuki Morishita
Takatoshi Iida
Daisuke Ishikawa
Kensaku Yamamoto