FLUOROETHER COMPOSITION AND METHOD FOR SUPPRESSING DEGRADATION OF THE SAME IN THE PRESENCE OF LEWIS ACID

Japanese Patent JP3664648

B2

PROBLEM TO BE SOLVED: To obtain a stable fluoroether composition for narcotic use non- degradable even in the presence of a Lewis acid, and to provide a method for suppressing the degradation of the fluoroether in the presence of a Lewis acid.
SOLUTION: This fluoroether composition which is a narcotic composition is obtained by including a given amount of sevoflurane and also a Lewis acid inhibitor other than an enough amount of water so as to prevent the above given amount of sevoflurane from being degraded. The Lewis acid inhibitor is particularly selected from the group consisting of butylated hydroxytoluene, methylparaben, propylparaben, propofol and thymol. The other objective method for suppressing the degradation of the above composition is also provided.

Christopher Biennial
Steve H. Jiang
Keith Earl Kromatsk
Xiuen El-Houin
Toshikazu Kawai
Manami Kobayashi
David Rotfredo
Radiago Paran Ragaban
Earl Earl Spiceer
Analyte A. Stelmatsu

JP2000349024A

June 29, 2005

January 23, 1998

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ABBOTT LABORATORIES

A61J3/00; A61K9/08; A61K31/08; A61K47/02; A61K47/04; A61J1/00; A61K47/10; A61K47/12; A61K47/14; A61P23/00; C07C63/04; C09K3/00; (IPC1-7): A61K31/08; A61K47/10; A61K47/14; A61P23/00; C07C63/04

JP5057182A

BASU P, et al.,Fluoroalkyl ether chemistry on alumina: A transmission infrared study of the adsorption and thermal ,Langmuir,1989年,Vol.5, No.2, 1989,p502-510

Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Naoya Fushimi

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