Title:
遺伝子発現の生体異物関連誘導
Document Type and Number:
Japanese Patent JP4446603
Kind Code:
B2
Abstract:
There is provided a non-human animal comprising a genetic construct, the genetic construct comprising: (i) a nucleotide sequence forming a transcriptional enhancer of human cytochrome P450 CYP3A4 production or expression, and (ii) a gene encoding a reporter molecule, wherein the nucleotide sequence includes each of the following nuclear response elements from the 5' flanking region of CYP3A4: SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 and SEQ ID NO: 5.
Inventors:
Riddle, Christopher
Goodwin, brian, james
Goodwin, brian, james
Application Number:
JP2000551006A
Publication Date:
April 07, 2010
Filing Date:
May 20, 1999
Export Citation:
Assignee:
The University of Sydney
International Classes:
C12N15/09; A01H5/00; A01K67/027; A01K67/033; C07K14/47; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/52; C12Q1/02; C12Q1/68; C12Q1/6897
Other References:
HASHIMOTO, H. et al.,"Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.",EUR. J. BIOCHEM.,1993年,Vol.218, No.2,p.585-595
BARWICK, J. L. et al.,"Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes.",MOL. PHARM.,1996年,Vol.50, No.1,p.10-16
OGG, M. S. et al.,"Development of an in vitro reporter gene assay to assess xenobiotic induction of the human CYP3A4 gene.",EUR. J. DRUG METAB. PHARMACOKINET.,1997年,Vol.22, No.4,p.311-313
KOVALEVA, I. E. et al.,"Transgenic yeast expressing human cytochrome P450s can serve as a tool in studies of the mechanisms of their induction by various effectors.",BIOCHEM. BIOPHYS. RES. COMMUN.,1996年 4月,Vol.221, No.1,p.129-132
YANAGIDA, A. et al.,"A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene.",MOL. CELL. BIOL.,1990年 4月,Vol.10, No.4,p.1470-1475
DOGRA, S. C. et al.,"Transcriptional activation of cytochrome P450 genes by different classes of chemical inducers.",CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,1998年,Vol.25, No.1,p.1-9
LEHMANN, J. M. et al.,"The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.",J. CLIN. INVEST.,1998年 9月,Vol.102, No.5,p.1016-1023
OURLIN, J. C. et al.,"Role of the liver-enriched transcription factors C/EBP alpha and DBP in the expression of human CYP3A4 and CYP3A7.",J. HEPATOL.,1997年,Vol.26, Suppl.2,p.54-62
BARWICK, J. L. et al.,"Trans-species gene transfer for analysis of glucocorticoid-inducible transcriptional activation of transiently expressed human CYP3A4 and rabbit CYP3A6 in primary cultures of adult rat and rabbit hepatocytes.",MOL. PHARM.,1996年,Vol.50, No.1,p.10-16
OGG, M. S. et al.,"Development of an in vitro reporter gene assay to assess xenobiotic induction of the human CYP3A4 gene.",EUR. J. DRUG METAB. PHARMACOKINET.,1997年,Vol.22, No.4,p.311-313
KOVALEVA, I. E. et al.,"Transgenic yeast expressing human cytochrome P450s can serve as a tool in studies of the mechanisms of their induction by various effectors.",BIOCHEM. BIOPHYS. RES. COMMUN.,1996年 4月,Vol.221, No.1,p.129-132
YANAGIDA, A. et al.,"A novel cis-acting DNA element required for a high level of inducible expression of the rat P-450c gene.",MOL. CELL. BIOL.,1990年 4月,Vol.10, No.4,p.1470-1475
DOGRA, S. C. et al.,"Transcriptional activation of cytochrome P450 genes by different classes of chemical inducers.",CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,1998年,Vol.25, No.1,p.1-9
LEHMANN, J. M. et al.,"The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.",J. CLIN. INVEST.,1998年 9月,Vol.102, No.5,p.1016-1023
OURLIN, J. C. et al.,"Role of the liver-enriched transcription factors C/EBP alpha and DBP in the expression of human CYP3A4 and CYP3A7.",J. HEPATOL.,1997年,Vol.26, Suppl.2,p.54-62
Attorney, Agent or Firm:
Nobuaki Kazehaya