Title:
脳のシャペロニンレベルを増大するための製剤及び方法
Document Type and Number:
Japanese Patent JP4965048
Kind Code:
B2
Abstract:
The invention includes; a method of modulating a level of chaperone protein, a method of modulating a level of ERP57, a method of alleviating a symptom of a disease associated with decreased levels of chaperone proteins, and a method of alleviating a symptom of Alzheimer's disease. The methods include administering to a patient a substituted biphenylmethane compound. Preferably the compound is an analog to methoxychlor. More preferably the compound is methoxychlor. The invention also includes pharmaceutical compositions. The pharmaceutical compositions include substituted biphenylmethanes and a pharmaceutically acceptable carrier. Preferably the pharmaceutical compositions include methoxychlor analogs and a pharmaceutically acceptable carrier. More preferably the pharmaceutical compositions include methoxychlor and a pharmaceutically acceptable carrier.
Inventors:
Holtzman, Jordan El.
Application Number:
JP2001585745A
Publication Date:
July 04, 2012
Filing Date:
May 23, 2001
Export Citation:
Assignee:
Holtzman, Jordan El.
International Classes:
A61K31/085; A61K31/00; A61K31/075; A61K31/09; A61K31/192; A61K31/235; A61K31/255; A61P25/28; A61P43/00
Foreign References:
| WO1999029657A1 | ||||
| WO2000026251A1 |
Other References:
MORRELL, S.L.,JOURNAL OF INVESTIGATIVE MEDICINE,1997年,Vol.45,No.7,P.345A
DOGDE,J.A. et al.,J. Steroid Biochem. Molec. Biol.,1996年,Vol.59, no.2,p.155-61
DOGDE,J.A. et al.,J. Steroid Biochem. Molec. Biol.,1996年,Vol.59, no.2,p.155-61
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji