Title:
創傷治癒調節のための製剤および方法
Document Type and Number:
Japanese Patent JP6927884
Kind Code:
B2
Abstract:
Methods and compounds are disclosed for wound healing by modulating autophagy. A formulation for modulating autophagy comprises a first modulating compound (FAM) selected from compounds having the general structure (I):wherein: L represents a linker selected from —C≡C—, (a tolan), —CH═CH— (a stilbene, preferably trans); or —CRa═CRb— a stilbene derivative; where Ra and Rb are independently H or phenyl optionally substituted with —(R3)p or —(R4)q;R1 to R4 are independent substituents at any available position of the phenyl rings, preferably at 3, 3′, 4, 4′, and/or 5, 5′; and m, n, p, and q are independently 0, 1, 2, or 3 representing the number of substituents of the rings, respectively, but at least one of m or n must be ≥1. Each R1 to R2 is independently selected from substituents described herein, including but not limited to hydroxyl, alkoxy, halo, halomethyl and glycosides. The formulation may also include an auxiliary autophagy modulating compound (AAM) as described herein. The formulation may include a hydrogel formed by the compounds themselves or otherwise and may include salts and/or complexes.
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Inventors:
Tsai, Chun-Che
McGuire, Karen, M.
Jamison, James, M.
Summers, Jack, Elle.
McGuire, Karen, M.
Jamison, James, M.
Summers, Jack, Elle.
Application Number:
JP2017553168A
Publication Date:
September 01, 2021
Filing Date:
April 07, 2016
Export Citation:
Assignee:
BioMendix LLC
International Classes:
A61K31/085; A61K9/06; A61K31/07; A61K31/09; A61K31/122; A61K31/198; A61K31/375; A61K31/7012; A61K47/36; A61K47/40; A61P17/02; A61P43/00
Foreign References:
| US7094809 | ||||
| WO2014074765A1 | ||||
| WO2009126700A1 |
Other References:
Am. J. Respir. Cell Mol. Biol,2015年 4月 6日,Vol. 53, No. 5,p. 637-646
Attorney, Agent or Firm:
Patent Service Corporation Tanigawa International Patent Office