Title:
FRAGMENT SIZE CHARACTERIZATION OF CELL-FREE DNA MUTATIONS FROM CLONAL HEMATOPOIESIS
Document Type and Number:
Japanese Patent JP2023089073
Kind Code:
A
Abstract:
To provide methods and systems for differentiating between cancer variants and somatic variants originating from hematopoietic cells in a cell-free DNA (cfDNA) sample.SOLUTION: Some embodiments provided herein relate to methods for differentiating cancer variants from hematopoietic cell variants in a circulating tumor DNA (ctDNA) sample. In some embodiments, the methods include: (a) obtaining a ctDNA sample comprising a plurality of cell-free DNA (cfDNA) fragments, or having the sample obtained; (b) extracting cfDNA fragments from the sample, where the cfDNA fragments include a plurality of variants; (c) performing molecular profiling for each of the variants; and (d) identifying cancer variants by removing the identified hematopoietic cell variants.SELECTED DRAWING: Figure 3
Inventors:
JIANG TINGTING
Application Number:
JP2023061390A
Publication Date:
June 27, 2023
Filing Date:
April 05, 2023
Export Citation:
Assignee:
ILLUMINA INC
International Classes:
C12Q1/68; C12M1/00; C12M1/34; C12Q1/04; C12Q1/6809; C12Q1/6869; C12Q1/6886; G16B20/20
Attorney, Agent or Firm:
Takeshi Oshio
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